The Picornaviruses
Author | : Ellie Ehrenfeld |
Publisher | : American Society for Microbiology Press |
Total Pages | : 1039 |
Release | : 2010-09-15 |
ISBN-10 | : 9781555816032 |
ISBN-13 | : 1555816037 |
Rating | : 4/5 (32 Downloads) |
Book excerpt: A springboard for developing new approaches to understanding, preventing, and treating picornaviral diseases. • Examines the most current breakthroughs as well as the challenges that lie ahead in picornavirus research; encapsulates current knowledge of the molecular biology, evolution, and pathogenesis of this large family of viruses; and, examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent and control those diseases. • Explores the structural and mechanistic bases of picornavirus replication, highlighting new insights about the host cell interactions needed for virus growth; and, illustrates how the regular occurrence of mutations, typical of viruses with RNA as genetic material, generates the quasispecies dynamics that underlie viral fitness. • Focuses on picornaviruses that cause disease, examining pathogenicity and innate and acquired immune responses against infection as well as the latest vaccine and antiviral drug strategies.